Yes. There is no drug interaction between Loratadine and Diphenhydramine. Just make sure to take a regular dose of both, and remember that Benadryl can make you drowsy. For chronic pain you are better off with a sustained release opiate rather then a quick release like vicodin or percocet. Those drugs are great for the odd time that you have break thru pain. Vicodin. Top-5 search term: Vicodin. People land here wanting to know how to “maximize the effects of Vicodin,” curious about what “chewing a Vicodin” will do. Doctors give trusted answers on uses, effects, side-effects, and cautions: Dr. Ali on can i take buspar and lexapro together: Sertraline and cipralex are both ssri antidepressants and do not need to be taken together. Your chance of developing side effects from too much serotonin increases when you take both together. Cipralex is also marketed. I believe taking that high dose made me biolar at age 34. I only take btwn 10-30 mg now and only for a few days in a row. I really am convinced that it made me bipolar. if I was addicited to vicodin and norco does that mean I can never take those meds, or all meds having opiates in them. what other medicine is there, with a narcotic in them? Beating cancer takes more than medicine. That’s why we do much more than breakthrough research. We also o er free rides to chemo, a live 24/7 helpline, and free lodging near hospitals for people dealing with every type of cancer. We’re attacking from every angle. The narcotics are not working, I am still in pain, no one will help and I can't take much more, I get up every day and wish that I didn't, there seems to be no light at the end of the tunnel and I am not sure how much more I can take, please help me if you can. You can indeed take both of these medications at the same time, and in fact your doctor may recommend that you do so. Before answering “can you take Xanax and melatonin,” what is Xanax? Xanax is a prescription benzodiazepine that’s given to patients who suffer from anxiety and panic disorders.